The Opposite of Sex marks the directorial debut for Don Roos, who also wrote the original screenplay.
Roos was born in New York in 1955. After a screenwriting course at the University of Notre Dame taught by alumnus Tony Bill, Roos moved to Hollywood in 1978. Eight years of writing and producing for television followed, until he took a sabbatical to write Love Field which he took to producers Midge Sanford and Sarah Pillsbury. The film was made and Michelle Pfeiffer won an Academy Award nomination for her role as Lurene Hallett, a Dallas housewife determined to attend the funeral of John F. Kennedy.
Next up was Single White Female, a 1992 contemporary thriller based on John Lutz's novel "S.W.F. Seeks Same" and directed by Barbet Schroeder. The film starred Bridget Fonda and Jennifer Jason Leigh in their breakout roles.
In late 1992, Roos wrote Boys on the Side, a road picture about a new kind of family, which he sold to New Regency Pictures. The movie, which opened in 1995, stars Whoopi Goldberg, Mary Louise Parker and Drew Barrymore in roles critics have deemed some of the best of their prospective careers. It was directed by Herb Ross and executive-produced by Roos and his partner Patricia Karlan.
His next film was Diabolique, a remake of the French classic, for producer Marvin Worth at Morgan Creek. Once again a Roos script drew top actresses to the leading roles, this time Sharon Stone, Isabelle Adjani and Kathy Bates.