When we meet Manni (Moritz Bleibtreu), a small time courier for big time gangster, he is working a standard pick-up/drop-off, and everything is going just fine. When the job is done, all he has to do is wait for his girlfriend, the orange-haired punk girl Lola (Franka Potente), to pick him up. But today is unlike any other day. Due to an incident while she was buying a pack of cigarettes, Lola is late, and Lola is never late. One stroke of bad luck leads to another, and by the time Manni calls Lola, he is at a pay phone with a big, big, big problem. His unforgiving boss will meet him in twenty minutes to pick up 100,000 marks; money that Manni, suddenly, does not have.
Lola rushes out of her apartment and down the street, attempting to get to Manni and, somehow, pick up 100,000 marks on the way. She tears through the city, in a whirl of bums, nuns, babies and guns. Down sidewalks, into offices, through traffic and back again. As her feet slap the pavement and the seconds tick down, the tiniest choices become life altering (or ending) decisions, and the fine line between fate and fortune begins to blur.